NLN Gene Summary [Human]
This gene encodes a member of the metallopeptidase M3 protein family that cleaves neurotensin at the Pro10-Tyr11 bond, leading to the formation of neurotensin(1-10) and neurotensin(11-13). The encoded protein is likely involved in the termination of the neurotensinergic signal in the central nervous system and in the gastrointestinal tract.[provided by RefSeq, Jun 2010]
Details
| Type | Protein Coding |
| Official Symbol | NLN |
| Official Name | neurolysin [Source:HGNC Symbol;Acc:HGNC:16058] |
| Ensembl ID | ENSG00000123213 |
| Bio databases IDs | |
| Aliases | neurolysin, neurotensin endopeptidase |
| Synonyms | 4930472G13RIK, AGTBP, Endopeptidase 3.4.24.16, EP24.16, MEP, MOP, neurolysin, neurolysin (metallopeptidase M3 family) |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NLN often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- neurolysin
- peptide binding
- endopeptidase
- peptidase
- Peptidase family M3
- peptidase GluZincin family
- metalloendopeptidase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- astigmatism
- major depression
- acne
- catalepsy
- Moyamoya disease
- alcoholism
role in cell
- differentiation
- gluconeogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- Plasma Membrane
- Mitochondria
- cytosol
- mitochondrial intermembrane space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NLN gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- peptide metabolic process
- proteolysis
- regulation of gluconeogenesis
Cellular Component
Where in the cell the gene product is active
- mitochondrial intermembrane space
- cytosol
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- peptide binding
- metalloendopeptidase activity