TNNC2 Gene Summary [Human]
Troponin (Tn), a key protein complex in the regulation of striated muscle contraction, is composed of 3 subunits. The Tn-I subunit inhibits actomyosin ATPase, the Tn-T subunit binds tropomyosin and Tn-C, while the Tn-C subunit binds calcium and overcomes the inhibitory action of the troponin complex on actin filaments. The protein encoded by this gene is the Tn-C subunit. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TNNC2 |
| Official Name | troponin C2, fast skeletal type [Source:HGNC Symbol;Acc:HGNC:11944] |
| Ensembl ID | ENSG00000101470 |
| Bio databases IDs | |
| Aliases | troponin C2, fast skeletal type |
| Synonyms | CFAP85, CMYO15, CMYP15, FAP85, MYONRI, TnCf, Tncs, Troponin c, troponin C2, fast, troponin C2, fast skeletal type |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TNNC2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand, calcium binding motif
- EF-hand domain
- EF-hand domain pair
- actin binding
- EF hand
- EF-hand, calcium binding motif, found in parvalbumin-like EF-hand family
- EFh
- protein binding
- EFh_MICU
- EFh_PI-PLC
Pathways
Biological processes and signaling networks where the TNNC2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypomagnesemia
- preeclampsia
- breast cancer
- osteopenia
- osteoporosis
- mammary neoplasm
- squamous-cell carcinoma
- squamous cell cancer
- renal osteodystrophy
- rheumatoid arthritis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TNNC2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- skeletal muscle contraction
- regulation of muscle contraction
Cellular Component
Where in the cell the gene product is active
- cytosol
- troponin complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding
- calcium ion binding