CARM1 Gene Summary [Human]
This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts specifically on histones and other chromatin-associated proteins and is involved in regulation of gene expression. The enzyme may act in association with other proteins or within multi-protein complexes and may play a role in cell type-specific functions and cell lineage specification. A related pseudogene is located on chromosome 9. [provided by RefSeq, Aug 2013]
Details
| Type | Protein Coding |
| Official Symbol | CARM1 |
| Official Name | coactivator associated arginine methyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:23393] |
| Ensembl ID | ENSG00000142453 |
| Bio databases IDs | |
| Aliases | coactivator associated arginine methyltransferase 1 |
| Synonyms | coactivator-associated arginine methyltransferase 1, m9Bei, PRMT4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CARM1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- activation domain
- transcription regulator
- transcription co-activator
- nucleic acid binding
- beta-catenin binding
- PRMT5 arginine-N-methyltransferase
- transcription activation domain
- transcription factor binding
- enzyme
- protein binding
- Pleckstrin homology-like domain
- AdoMet_MTases
- protein-arginine N-methyltransferase
- sequence-specific DNA binding
- methyltransferase domain
- phosphorylation site
- histone-arginine N-methyltransferase
- protein methyltransferase
- histone methyltransferase
- double-stranded DNA binding
Pathways
Biological processes and signaling networks where the CARM1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- organismal death
- lung squamous cell carcinoma
- squamous cell lung cancer
- breast cancer
- plasma cell myeloma
- prostate cancer
- acute coronary syndrome
role in cell
- expression in
- apoptosis
- proliferation
- activation in
- transcription in
- differentiation
- phosphorylation in
- binding in
- cell proliferation
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nucleoplasm
- nuclear envelope
- replication fork
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CARM1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of dendrite development
- chromatin remodeling
- peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
- positive regulation of cell proliferation
- regulation of transcription, DNA-dependent
- response to cAMP
- positive regulation of fat cell differentiation
- regulation of intracellular estrogen receptor signaling pathway
- replication fork reversal
- methylation
- positive regulation of transcription from RNA polymerase I promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear replication fork
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein-arginine omega-N asymmetric methyltransferase activity
- protein methyltransferase activity
- transcription regulatory region sequence-specific DNA binding
- beta-catenin binding
- histone-arginine N-methyltransferase activity
- protein binding
- transcription coactivator activity
- histone methyltransferase activity
- histone acetyl-lysine binding
- protein-arginine N-methyltransferase activity
- ligand-dependent nuclear receptor transcription coactivator activity
- histone methyltransferase activity (H3-R2 specific)
- histone methyltransferase activity (H3-R17 specific)