CD3E Gene Summary [Human]
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]
Details
| Type | Retained Intron |
| Official Symbol | CD3E |
| Official Name | CD3e molecule [Source:HGNC Symbol;Acc:HGNC:1674] |
| Ensembl ID | ENSG00000198851 |
| Bio databases IDs | |
| Aliases | CD3e molecule, CD3 epsilon subunit of T-cell receptor complex, T-cell surface glycoprotein CD3 epsilon chain |
| Synonyms | CD3, CD3A, CD3 antigen, epsilon polypeptide, CD3 antigen, ε polypeptide, CD3epsilon, CD3 (epsilon chain), CD3 epsilon subunit of T-cell receptor complex, Cd3-ε, CD3 (ε chain), CD3 ε subunit of T-cell receptor complex, IMD18, T3E, TCR, TCRE, Tcr-epsilon, Tcr-ε |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CD3E often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleolin binding domain
- Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain
- immunoglobulin domain
- protein binding
- proline rich domain
- identical protein binding
- SH3-domain binding
- T-cell surface glycoprotein CD3 delta chain
- phosphorylation site
- arginine-lysine rich domain
- ER retention sequence
- itam like domain
- cytoplasmic domain
- stalk region
- CXXC motif
- Immunoreceptor tyrosine-based activation motif
- intracellular domain
- cytosolic tail domain
- transmembrane receptor
Pathways
Biological processes and signaling networks where the CD3E gene in human plays a role, providing insight into its function and relevance in health or disease.
- Allograft Rejection Signaling
- Antiproliferative Role of TOB in T Cell Signaling
- Autoimmune Thyroid Disease Signaling
- Calcium-induced T Lymphocyte Apoptosis
- CCR5 Signaling in Macrophages
- CTLA4 Signaling in Cytotoxic T Lymphocytes
- Cytotoxic T Lymphocyte-mediated Apoptosis of Target Cells
- Dendritic Cell Maturation
- G Protein Signaling Mediated by Tubby
- Glucocorticoid Receptor Signaling
- Graft-versus-Host Disease Signaling
- IL-4 Signaling
- Lipid Antigen Presentation by CD1
- NF-κB Signaling
- Nur77 Signaling in T Lymphocytes
- OX40 Signaling Pathway
- PKCθ Signaling in T Lymphocytes
- Primary Immunodeficiency Signaling
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- SAPK/JNK Signaling
- TEC Kinase Signaling
- Th1 and Th2 Activation Pathway
- Th1 Pathway
- Th17 Activation Pathway
- Th2 Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- T-cell/histiocyte rich large B-cell lymphoma
- precursor B-cell acute lymphoblastic leukemia
- epithelial cancer
- myasthenia gravis
- immunodeficiency 18 severe combined immunodeficiency variant
- B-cell acute lymphoblastic lymphoma
- cancer
- acute lymphoblastic lymphoma
- immunodeficiency 18
role in cell
- activation in
- proliferation
- expression in
- growth
- differentiation
- phosphorylation in
- apoptosis
- cell viability
- binding
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-insoluble membrane fraction
- soluble fraction
- membrane fraction
- Cytoplasm
- cell surface
- intracellular space
- cellular membrane
- Nucleus
- Golgi Apparatus
- Endoplasmic Reticulum
- intercellular junctions
- immunological synapses
- microsome
- plasma membrane extracellular face
- nuclear envelope
- dendritic spines
- membrane rafts
- perikaryon
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CD3E gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal complex assembly
- T cell activation
- apoptotic signaling pathway
- alpha-beta T cell activation
- positive regulation of calcium-mediated signaling
- CD4-positive, alpha-beta T cell proliferation
- positive regulation of interferon-gamma production
- calcium-mediated signaling
- positive regulation of cell-cell adhesion mediated by integrin
- positive regulation of peptidyl-tyrosine phosphorylation
- T cell receptor signaling pathway
- dendrite development
- positive regulation of interleukin-2 production
- gamma-delta T cell activation
- T cell costimulation
- G-protein coupled receptor signaling pathway
- macromolecular complex assembly
- cerebellum development
- adaptive immune response
- transmembrane receptor protein tyrosine kinase signaling pathway
- smoothened signaling pathway
- regulation of apoptotic process
- cell surface receptor signaling pathway
- positive thymic T cell selection
- positive regulation of T cell proliferation
- negative regulation of smoothened signaling pathway
- T cell anergy
- negative regulation of gene expression
- positive regulation of T cell anergy
- positive regulation of cell-matrix adhesion
- positive regulation of gene expression
- negative thymic T cell selection
- positive regulation of CD4-positive, alpha-beta T cell proliferation
- positive regulation of interleukin-4 production
Cellular Component
Where in the cell the gene product is active
- cell-cell junction
- dendritic spine
- cell body
- external side of plasma membrane
- T cell receptor complex
- endoplasmic reticulum
- Golgi apparatus
- plasma membrane
- alpha-beta T cell receptor complex
- immunological synapse
- gamma-delta T cell receptor complex
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- identical protein binding
- transmembrane signaling receptor activity
- protein binding
- T cell receptor binding
- SH3 domain binding
- receptor signaling complex scaffold activity