UNC5CL Gene Summary [Human]
Enables peptidase activity. Acts upstream of or within positive regulation of I-kappaB kinase/NF-kappaB signaling and positive regulation of JNK cascade. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | UNC5CL |
| Official Name | unc-5 family C-terminal like [Source:HGNC Symbol;Acc:HGNC:21203] |
| Ensembl ID | ENSG00000124602 |
| Bio databases IDs | |
| Aliases | unc-5 family C-terminal like, ZU5 and death domain containing |
| Synonyms | 2510009H09RIK, AC165291.1, MUXA, unc-5 family C-terminal like, ZUD |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human UNC5CL often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Death domain
- peptidase
- protein binding
- Death Domain Superfamily of protein-protein interaction domains
- UPA domain
- ZU5 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- centrosome
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human UNC5CL gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of JNK cascade
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- netrin-activated signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- netrin receptor activity
- peptidase activity