KLHDC3 Gene Summary [Human]
The protein encoded by this gene contains six repeated kelch motifs that are structurally similar to recombination activating gene 2, a protein involved in the activation of the V(D)J recombination. In mouse, this gene is found to be expressed specifically in testis. Its expression in pachytene spermatocytes is localized to cytoplasma and meiotic chromatin, suggesting that this gene may be involved in meiotic recombination. [provided by RefSeq, Jun 2012]
Details
| Type | Protein Coding |
| Official Symbol | KLHDC3 |
| Official Name | kelch domain containing 3 [Source:HGNC Symbol;Acc:HGNC:20704] |
| Ensembl ID | ENSG00000124702 |
| Bio databases IDs | |
| Aliases | kelch domain containing 3 |
| Synonyms | 1300011D16Rik, dJ20C7.3, kelch domain containing 3, PEAS |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KLHDC3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Galactose oxidase, central domain
- Kelch motif
- protein binding activity, bridging
- chromatin binding
- protein binding
- Kelch domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
role in cell
- binding in
- proliferation
- gefitinib sensitivity
- degradation in
- osimertinib sensitivity
- Met1 linked ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KLHDC3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- reciprocal meiotic recombination
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- Cul2-RING ubiquitin ligase complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- chromatin binding