INPP5F Gene Summary [Human]
The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase and contains a Sac domain. The activity of this protein is specific for phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | INPP5F |
| Official Name | inositol polyphosphate-5-phosphatase F [Source:HGNC Symbol;Acc:HGNC:17054] |
| Ensembl ID | ENSG00000198825 |
| Bio databases IDs | |
| Aliases | inositol polyphosphate-5-phosphatase F, Phosphatidylinositide phosphatase SAC2, Sac domain-containing inositol phosphatase 2, Sac domain-containing phosphoinositide 4-phosphatase 2 |
| Synonyms | 5830435P03Rik, cI-27, hSAC2, inositol polyphosphate-5-phosphatase F, LOC103690084, mKIAA0966, MSTP007, MSTPO47, SAC2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human INPP5F often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
- Inositol phosphatase
- inositol-polyphosphate 5-phosphatase
- phosphatase
- protein homodimerization
- inositol-1(or 4)-monophosphatase
- protein binding
- phosphoinositide 5-phosphatase
- SacI homology domain
Pathways
Biological processes and signaling networks where the INPP5F gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- liver cancer
- hepatocellular carcinoma
- Parkinson disease
- organismal death
- chronic lymphocytic leukemia
- REM sleep behavior disorder
- non-insulin-dependent diabetes mellitus
- dystrophy
role in cell
- accumulation in
- expression in
- proliferation
- growth
- regeneration
- upregulation in
- regeneration in
- growth in
- reformation
- reformation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- Cytoplasm
- endosomal membrane
- recycling endosomes
- early endosomes
- endocytotic vesicle
- clathrin-coated pits
- membrane processes
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human INPP5F gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phosphatidylinositol catabolic process
- adult locomotory behavior
- phosphatidylinositol biosynthetic process
- negative regulation of tyrosine phosphorylation of STAT protein
- phosphatidylinositol dephosphorylation
- clathrin-mediated endocytosis
- regulation of protein kinase B signaling cascade
- protein kinase B signaling cascade
- negative regulation of axon regeneration
- positive regulation of receptor recycling
- phosphatidylinositol-mediated signaling
- negative regulation of peptidyl-serine phosphorylation
- regulation of cell motility
- cardiac muscle hypertrophy in response to stress
- regulation of endocytic recycling
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- dendrite
- early endosome
- intracellular membrane-bounded organelle
- coated pit
- recycling endosome
- clathrin-coated endocytic vesicle
- neuronal cell body
- axon
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-4-phosphate phosphatase activity
- protein binding
- inositol monophosphate 1-phosphatase activity
- protein homodimerization activity
- phosphatidylinositol phosphate 4-phosphatase activity
- phosphatidylinositol phosphate 5-phosphatase activity
- inositol monophosphate 3-phosphatase activity
- inositol monophosphate 4-phosphatase activity