GLO1 Gene Summary [Human]
The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | GLO1 |
| Official Name | glyoxalase I [Source:HGNC Symbol;Acc:HGNC:4323] |
| Ensembl ID | ENSG00000124767 |
| Bio databases IDs | |
| Aliases | glyoxalase I, lactoylglutathione lyase |
| Synonyms | 0610009E22Rik, 1110008E19Rik, 2510049H23Rik, Glo-1r, Glo-1s, GLOD1, GLY1, GLYI, Glyoxalase 1, glyoxalase I, Glyoxylase, GLYOXYLASE I, HEL-S-74, LACTOYL GLUTATHIONE LYASE, Qglo |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GLO1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc ion binding
- glyoxalase I/type I extradiol dioxygenase/antibiotic resistance protein metal-binding domain
- lactoylglutathione lyase
- enzyme
- protein binding
- Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- myocardial fibrosis
- breast cancer
- major depression
- insomnia
- preeclampsia
- idiopathic scoliosis
role in cell
- apoptosis
- proliferation
- phosphorylation in
- migration
- cell death
- differentiation
- invasion by
- cellular infiltration by
- internalization by
- endoplasmic reticulum stress response in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GLO1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- osteoclast differentiation
- carbohydrate metabolic process
- negative regulation of apoptotic process
- glutathione metabolic process
- methylglyoxal metabolic process
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- lactoylglutathione lyase activity