CHAF1A Gene Summary [Human]
Chromatin assembly factor I (CAF1) is a nuclear complex consisting of p50, p60 (CHAF1B; MIM 601245), and p150 (CHAF1A) subunits that assembles histone octamers onto replicating DNA in vitro (Kaufman et al., 1995 [PubMed 7600578]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | CHAF1A |
| Official Name | chromatin assembly factor 1 subunit A [Source:HGNC Symbol;Acc:HGNC:1910] |
| Ensembl ID | ENSG00000167670 |
| Bio databases IDs | |
| Aliases | chromatin assembly factor 1 subunit A, chromatin assembly factor I (150 kDa) |
| Synonyms | AL023013, AL024058, Cac1p, CAF-1, CAF1B, CAF1P150, CHAFIA, chromatin assembly factor 1 subunit A, chromatin assembly factor 1, subunit A, HP150, LOC107985297, P150 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CHAF1A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CAF1 complex subunit p150, region binding to CAF1-p60 at C-term
- PEST domain
- PCNA binding domain
- dimerization domain
- Chromatin assembly factor 1 complex p150 subunit, N-terminal
- CAF1 complex subunit p150, region binding to PCNA
- KER domain
- protein domain specific binding
- chromatin binding
- protein binding
- identical protein binding
- ED domain
Pathways
Biological processes and signaling networks where the CHAF1A gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Goldenhar syndrome
- glioma formation
- organismal death
- glioma
- Waldenström macroglobulinemia
- colon cancer
- colon carcinoma
- colon epithelial cancer
- infection by HIV-1
role in cell
- accumulation in
- replication in
- activation in
- proliferation
- expression in
- apoptosis
- migration
- cell viability
- differentiation
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- heterochromatin
- nuclear foci
- nucleoplasm
- nucleoli
- perichromosomal layer
- DNA replication foci
- chromatin
- pericentric heterochromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CHAF1A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- DNA replication
- nucleosome assembly
- DNA replication-dependent nucleosome assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- CAF-1 complex
- macromolecular complex
- chromatin
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- chromo shadow domain binding
- unfolded protein binding
- chromatin binding