POLR1B Gene Summary [Human]
Eukaryotic RNA polymerase I (pol I) is responsible for the transcription of ribosomal RNA (rRNA) genes and production of rRNA, the primary component of ribosomes. Pol I is a multisubunit enzyme composed of 6 to 14 polypeptides, depending on the species. Most of the mass of the pol I complex derives from the 2 largest subunits, Rpa1 and Rpa2 in yeast. POLR1B is homologous to Rpa2 (Seither and Grummt, 1996 [PubMed 8921381]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | POLR1B |
| Official Name | RNA polymerase I subunit B [Source:HGNC Symbol;Acc:HGNC:20454] |
| Ensembl ID | ENSG00000125630 |
| Bio databases IDs | |
| Aliases | RNA polymerase I subunit B |
| Synonyms | A127, A135, D630020H17Rik, polymerase (RNA) I polypeptide B, RNA polymerase I subunit B, RPA116, RPA135, RPA2, RPO1-2, TCS4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human POLR1B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ricin-type beta-trefoil lectin domain
- DNA-directed RNA polymerase
- nucleic acid binding
- RNA_pol_B_RPB2
- enzyme
- protein binding
- RNA polymerase beta subunit
- RNA polymerase Rpb2, domain 6
- zinc ion binding
- RNA polymerase Rpb2, domain 3
- RNA polymerase Rpb2, domain 2
- DNA-directed RNA polymerase subunit B
- RNA polymerase Rpb2, domain 7
Pathways
Biological processes and signaling networks where the POLR1B gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- fibrillar center
- Cytoplasm
- cytosol
- chromosome
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human POLR1B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription from RNA polymerase I promoter
- rRNA transcription
- nucleologenesis
- neural crest formation
- embryo implantation
Cellular Component
Where in the cell the gene product is active
- DNA-directed RNA polymerase I complex
- cytosol
- chromosome
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- zinc ion binding
- ribonucleoside binding
- DNA-directed RNA polymerase activity
- RNA polymerase I activity
- protein binding
- DNA/RNA hybrid binding