Polr1b Gene Summary [Mouse]
Predicted to enable DNA/RNA hybrid binding activity and zinc ion binding activity. Predicted to contribute to DNA-directed RNA polymerase activity. Acts upstream of or within embryo implantation; nucleologenesis; and rRNA transcription. Located in chromosome and nucleolus. Part of RNA polymerase I complex. Is expressed in several structures, including alimentary system; central nervous system; heart; integumental system; and respiratory system. Human ortholog(s) of this gene implicated in Treacher Collins syndrome 4. Orthologous to human POLR1B (RNA polymerase I subunit B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Polr1b |
| Official Name | polymerase (RNA) I polypeptide B [Source:MGI Symbol;Acc:MGI:108014] |
| Ensembl ID | ENSMUSG00000027395 |
| Bio databases IDs | |
| Aliases | polymerase (RNA) I polypeptide B |
| Synonyms | A127, A135, D630020H17Rik, polymerase (RNA) I polypeptide B, RNA polymerase I subunit B, RPA116, RPA135, RPA2, RPO1-2, TCS4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Polr1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ricin-type beta-trefoil lectin domain
- DNA-directed RNA polymerase
- nucleic acid binding
- RNA_pol_B_RPB2
- enzyme
- protein binding
- RNA polymerase beta subunit
- RNA polymerase Rpb2, domain 6
- zinc ion binding
- RNA polymerase Rpb2, domain 3
- RNA polymerase Rpb2, domain 2
- DNA-directed RNA polymerase subunit B
- RNA polymerase Rpb2, domain 7
Pathways
Biological processes and signaling networks where the Polr1b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- fibrillar center
- Cytoplasm
- cytosol
- chromosome
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Polr1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription from RNA polymerase I promoter
- rRNA transcription
- nucleologenesis
- neural crest formation
- embryo implantation
Cellular Component
Where in the cell the gene product is active
- DNA-directed RNA polymerase I complex
- cytosol
- chromosome
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- zinc ion binding
- ribonucleoside binding
- DNA-directed RNA polymerase activity
- RNA polymerase I activity
- protein binding
- DNA/RNA hybrid binding