STK35 Gene Summary [Human]
The protein encoded by this gene is a kinase that is predominantly found in the nucleus. However, it can interact with PDLIM1/CLP-36 in the cytoplasm and localize to actin stress fibers. The encoded protein may be a regulator of actin stress fibers in nonmuscle cells. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | STK35 |
| Official Name | serine/threonine kinase 35 [Source:HGNC Symbol;Acc:HGNC:16254] |
| Ensembl ID | ENSG00000125834 |
| Bio databases IDs | |
| Aliases | serine/threonine kinase 35, CLP-36 interacting kinase |
| Synonyms | 1700054C12RIK, CLIK1, serine/threonine kinase 35, STK35L1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human STK35 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- cancer
- non-insulin-dependent diabetes mellitus
- lung cancer
- anterior adhesions of iris
- refractive error
- colorectal cancer
- microphthalmia
- sarcoma
- spontaneous preterm birth
role in cell
- expression in
- apoptosis
- migration
- number
- abnormal morphology
- organization
- cohesion in
- cohesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- nucleoplasm
- nucleoli
- nuclear bodies
- actin stress fibers
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human STK35 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translational initiation by eIF2 alpha phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- cytoplasm
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- eukaryotic translation initiation factor 2alpha kinase activity