CTDSPL2 Gene Summary [Human]
Enables RNA polymerase II CTD heptapeptide repeat phosphatase activity. Predicted to act upstream of or within negative regulation of BMP signaling pathway; positive regulation of protein export from nucleus; and protein dephosphorylation. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CTDSPL2 |
| Official Name | CTD small phosphatase like 2 [Source:HGNC Symbol;Acc:HGNC:26936] |
| Ensembl ID | ENSG00000137770 |
| Bio databases IDs | |
| Aliases | CTD small phosphatase like 2 |
| Synonyms | CTD small phosphatase like 2, D2Ertd485e, HSPC058, HSPC129, RGD1309219, SCP4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CTDSPL2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CTD phosphatase
- FCP1-like phosphatase, phosphatase domain
- protein phosphatase
- phosphatase
- protein binding
- Haloacid Dehalogenase-like Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CTDSPL2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of BMP signaling pathway
- positive regulation of protein export from nucleus
- protein export from nucleus
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- phosphoprotein phosphatase activity
- protein binding
- CTD phosphatase activity