DSTN Gene Summary [Human]
The product of this gene belongs to the actin-binding proteins ADF family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin). Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | DSTN |
| Official Name | destrin, actin depolymerizing factor [Source:HGNC Symbol;Acc:HGNC:15750] |
| Ensembl ID | ENSG00000125868 |
| Bio databases IDs | |
| Aliases | destrin, actin depolymerizing factor |
| Synonyms | 2610043P17Rik, ACTDP, ADF, bA462D18.2, corn1, Destrin, destrin, actin depolymerizing factor, Dsn, HEL32, sid23p |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DSTN often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- Cofilin/tropomyosin-type actin-binding protein
- Actin depolymerization factor/cofilin- and gelsolin-like domains
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic sinusitis
- autosomal dominant polycystic kidney disease
- idiopathic membranous nephropathy
- gastric carcinoma
- gastric epithelial cancer
regulates
- F Actin
- actin
- Alpha actin
- G-actin
- Actomyosin
role in cell
- size
- fragmentation
- amoeboid motility
- motility
- polymerization
- cytokinesis in
- depolymerization
- turnover
- cytokinesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- stereocilia tip
- glutaminergic synapse
- cortical actin cytoskeleton
- presynaptic regions
- postsynaptic region
- actin cytoskeleton
- cytosol
- perinuclear space
- growth cone
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DSTN gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell motility
- actin filament severing
- positive regulation of actin filament depolymerization
- actin polymerization or depolymerization
- actin filament depolymerization
- actin filament fragmentation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- actin cytoskeleton
- cortical actin cytoskeleton
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding