Dstn Gene Summary [Mouse]
Enables actin filament binding activity. Involved in actin filament fragmentation. Acts upstream of or within cell motility and positive regulation of actin filament depolymerization. Located in cortical actin cytoskeleton. Is active in glutamatergic synapse; postsynapse; and presynapse. Is expressed in several structures, including genitourinary system; gut; nervous system; sensory organ; and skin. Orthologous to human DSTN (destrin, actin depolymerizing factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dstn |
| Official Name | destrin [Source:MGI Symbol;Acc:MGI:1929270] |
| Ensembl ID | ENSMUSG00000015932 |
| Bio databases IDs | |
| Aliases | destrin |
| Synonyms | 2610043P17Rik, ACTDP, ADF, bA462D18.2, corn1, Destrin, destrin, actin depolymerizing factor, Dsn, HEL32, sid23p |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dstn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- Cofilin/tropomyosin-type actin-binding protein
- Actin depolymerization factor/cofilin- and gelsolin-like domains
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic sinusitis
- autosomal dominant polycystic kidney disease
- idiopathic membranous nephropathy
- gastric carcinoma
- gastric epithelial cancer
regulates
- F Actin
- actin
- Alpha actin
- G-actin
- Actomyosin
role in cell
- size
- fragmentation
- amoeboid motility
- motility
- polymerization
- cytokinesis in
- depolymerization
- turnover
- cytokinesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- stereocilia tip
- glutaminergic synapse
- cortical actin cytoskeleton
- presynaptic regions
- postsynaptic region
- actin cytoskeleton
- cytosol
- perinuclear space
- growth cone
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dstn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell motility
- actin filament severing
- positive regulation of actin filament depolymerization
- actin polymerization or depolymerization
- actin filament depolymerization
- actin filament fragmentation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- actin cytoskeleton
- cortical actin cytoskeleton
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding