KRT6C
KRT6C Gene Summary
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. The type II keratins are clustered in a region of chromosome 12q13. [provided by RefSeq, Jul 2009]
Details
| Type | Protein Coding |
| Official Symbol | KRT6C |
| Official Name | keratin 6C [Source:HGNC Symbol;Acc:HGNC:20406] |
| Ensembl ID | ENSG00000170465 |
| Bio databases IDs | |
| Aliases | keratin 6C |
| Synonyms | CK 6E,Cytokeratin 6E,K6E,K6e keratin,keratin 6C,KRT6E,PPKNEFD |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Intermediate filament protein
- Keratin type II head
Pathways
Biological processes and signaling networks where the KRT6C gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- FLNC
- KRT16
- GOLGA2
- EZH2
- KRT36
- RPH3AL
- LIN7C
- KRT7
- COPS5
- YAP1
disease
- psoriasis
- focal palmoplantar keratoderma
- focal or diffuse nonepidermolytic palmoplantar keratoderma
- delayed hypersensitive reaction
- plaque psoriasis
regulated by
- TP63
- FOXC1
- KMT2D
- OGA
- SETX
regulates
role in cell
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the KRT6C gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- intermediate filament cytoskeleton organization
- keratinization
- intermediate filament organization
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular vesicular exosome
- keratin filament
- cytosol
- intermediate filament
MOLECULAR FUNCTION
What the gene product does at the molecular level
- structural constituent of epidermis
- protein binding