IFI6
IFI6 Gene Summary
This gene was first identified as one of the many genes induced by interferon. The encoded protein may play a critical role in the regulation of apoptosis. A minisatellite that consists of 26 repeats of a 12 nucleotide repeating element resembling the mammalian splice donor consensus sequence begins near the end of the second exon. Alternatively spliced transcript variants that encode different isoforms by using the two downstream repeat units as splice donor sites have been described. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | IFI6 |
| Official Name | interferon alpha inducible protein 6 [Source:HGNC Symbol;Acc:HGNC:4054] |
| Ensembl ID | ENSG00000126709 |
| Bio databases IDs | |
| Aliases | interferon alpha inducible protein 6 |
| Synonyms | 6-16,FAM14C,G1P3,IFI-6-16,IFI6-26,IFN6-16,IFN alpha REGULATED,IFN α REGULATED,INTERFERON alpha INDUCIBLE,interferon alpha inducible protein 6,INTERFERON INDUCIBLE PEPTIDE (6-16),INTERFERON α INDUCIBLE,interferon α inducible protein 6,ISG6-16 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Interferon-induced 6-16 family
- protein binding
Pathways
Biological processes and signaling networks where the IFI6 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- ESR2
- IRF8
- SREK1
- APP
- STAT1
- ELAVL1
- WBP11
- CDC5L
- H2AC20
- CABIN1
disease
- skin basal cell carcinoma
- COVID-19
- systemic lupus erythematosus
- hyperzincemia and hypercalprotectinemia autoinflammatory syndrome
- lichen planus
- cutaneous T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- skin cancer
- ATAD3A-related type I interferonopathy
regulated by
- tretinoin
- ESR1
- TNF
- lipopolysaccharide
- KRAS
- A549 cells
- interferon alpha
- poly rI:rC-RNA
- IFN type 1
- NS1
regulates
- reactive oxygen species
- BCL2
- estrogen receptor
- BCL2L11
role in cell
- apoptosis
- transmembrane potential
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- mitochondrial fraction
- Plasma Membrane
- Mitochondria
- endoplasmic reticulum membrane
- mitochondrial membrane
- mitochondrial outer membrane
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the IFI6 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
- apoptotic signaling pathway
- intrinsic apoptotic signaling pathway
- regulation of epidermal growth factor receptor signaling pathway
- reactive oxygen species metabolic process
- immune response
- innate immune response
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
- negative regulation of apoptotic process
- apoptotic process
- release of cytochrome c from mitochondria
- defense response to virus
- negative regulation of mitochondrial depolarization
CELLULAR COMPONENT
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- mitochondrial membrane
- mitochondrion
- plasma membrane
- mitochondrial inner membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding