SREK1 Gene Summary [Human]
This gene encodes a member of a family of serine/arginine-rich (SR) splicing proteins containing RNA recognition motif (RRM) domains. The encoded protein interacts with other SR proteins to modulate splice site selection. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Details
| Type | Protein Coding |
| Official Symbol | SREK1 |
| Official Name | splicing regulatory glutamic acid and lysine rich protein 1 [Source:HGNC Symbol;Acc:HGNC:17882] |
| Ensembl ID | ENSG00000153914 |
| Bio databases IDs | |
| Aliases | splicing regulatory glutamic acid and lysine rich protein 1, serine-arginine-rich splicing regulatory protein 508 |
| Synonyms | 8430401B01, AL118220, SFRS12, splicing regulatory glutamic acid and lysine rich protein 1, splicing regulatory glutamine/lysine-rich protein 1, SRrp508, SRrp86, Srsf12 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SREK1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glutamic acid-lysine rich domain
- arginine serine dipeptide repeat domain
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- protein binding
- SR domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SREK1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- mRNA processing
Cellular Component
Where in the cell the gene product is active
- nuclear speck
- spliceosomal complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding