SGPP1 Gene Summary [Human]
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. SGPP1 catalyzes the degradation of S1P via salvage and recycling of sphingosine into long-chain ceramides (Mandala et al., 2000 [PubMed 10859351]; Le Stunff et al., 2007 [PubMed 17895250]).[supplied by OMIM, Jun 2009]
Details
| Type | Protein Coding |
| Official Symbol | SGPP1 |
| Official Name | sphingosine-1-phosphate phosphatase 1 [Source:HGNC Symbol;Acc:HGNC:17720] |
| Ensembl ID | ENSG00000126821 |
| Bio databases IDs | |
| Aliases | sphingosine-1-phosphate phosphatase 1 |
| Synonyms | LOC81536, SGPP2, SP1 PHOSPHATASE, sphingosine-1-phosphate phosphatase 1, SPP, SPP-1, SPP2, SPPase1, Spph1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SGPP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Acid phosphatase homologues
- PAP2 superfamily
- sphingosine-1-phosphate phosphatase
- phosphatase
- PAP2_like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- complication
- chronic lymphocytic leukemia
- allergic rhinitis
- desquamation
- dextran sodium sulfate-induced colitis
- mucopolysaccharidosis type IVB
- ichthyosis
role in cell
- activation in
- apoptosis
- cell viability
- expression in
- production in
- differentiation
- migration
- infiltration by
- chemotaxis
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cellular membrane
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SGPP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phospholipid dephosphorylation
- sphinganine-1-phosphate metabolic process
- regulation of keratinocyte differentiation
- sphingosine metabolic process
- regulation of epidermis development
- extrinsic apoptotic signaling pathway
- intrinsic apoptotic signaling pathway
- ER to Golgi ceramide transport
- sphingolipid catabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- sphingosine-1-phosphate phosphatase activity
- dihydrosphingosine-1-phosphate phosphatase activity