SYP Gene Summary [Human]
This gene encodes an integral membrane protein of small synaptic vesicles in brain and endocrine cells. The protein also binds cholesterol and is thought to direct targeting of vesicle-associated membrane protein 2 (synaptobrevin) to intracellular compartments. Mutations in this gene are associated with an X-linked form of cognitive disability. [provided by RefSeq, Jul 2017]
Details
| Type | Protein Coding |
| Official Symbol | SYP |
| Official Name | synaptophysin [Source:HGNC Symbol;Acc:HGNC:11506] |
| Ensembl ID | ENSG00000102003 |
| Bio databases IDs | |
| Aliases | synaptophysin |
| Synonyms | A230093K24RIK, MRX96, MRXSYP, p38, Syn, synaptophysin, Synaptophysin1, Syp1, XLID96 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SYP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Membrane-associating domain
- SNARE binding
- cholesterol binding
- binding protein
- SH2-domain binding
- syntaxin-1 binding
- protein domain specific binding
- protein binding
- cytosolic tail domain
- identical protein binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- schizophrenia
- epithelial cancer
- Alzheimer disease
- neuroendocrine carcinoma
- neuroendocrine cancer
- x-linked mental retardation type 96
- obesity
- Merkel-cell carcinoma
- Merkel cell cancer
role in cell
- formation
- endocytosis
- priming
- endocytosis by
- paired-pulse facilitation
- recovery in
- synaptic transmission in
- plasticity
- long-term potentiation
- recycling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- synaptic plasma membrane fractions
- soluble fraction
- postsynaptic density (PSD) fractions
- membrane fraction
- synaptosomal membrane fractions
- synaptic vesicle membrane
- proximal axon
- presynaptic regions
- cell surface
- cell periphery
- basal compartment
- perinuclear region
- intracellular membranes
- cellular membrane
- vacuole
- Plasma Membrane
- vesicles
- granules
- cytosol
- presynaptic membrane
- synaptic membrane
- dendritic spines
- synaptic vesicles
- neuromuscular junctions
- neurites
- nerve ending
- synaptosomes
- synapse
- photoreceptor outer segments
- early endosomes
- transport vesicles
- dense-core vesicles
- endocytotic vesicle
- synaptic-like microvesicles
- membrane rafts
- cellular protrusions
- membrane processes
- perikaryon
- axons
- dendrites
- postsynaptic density
- axon terminals
- presynaptic terminals
- neuromuscular synapse
- excitatory synapses
- clathrin-coated vesicles
- mossy fibers
- vesicle fraction
- synaptic vesicle fractions
- synaptosomal fractions
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SYP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- synaptic vesicle endocytosis
- synaptic vesicle membrane organization
- regulation of long-term neuronal synaptic plasticity
- regulation of neuronal synaptic plasticity
- regulation of synaptic vesicle exocytosis
- synaptic vesicle maturation
- endocytosis
- regulation of short-term neuronal synaptic plasticity
- regulation of opioid receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- perinuclear region of cytoplasm
- presynaptic active zone
- terminal button
- synaptic vesicle
- excitatory synapse
- neuromuscular junction
- synaptic vesicle membrane
- neuron projection
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- cholesterol binding
- SH2 domain binding