PPCS Gene Summary [Human]
Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCS (EC 6.3.2.5), one of the last enzymes in this pathway, converts phosphopantothenate to phosphopantothenoylcysteine (Daugherty et al., 2002 [PubMed 11923312]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | PPCS |
| Official Name | phosphopantothenoylcysteine synthetase [Source:HGNC Symbol;Acc:HGNC:25686] |
| Ensembl ID | ENSG00000127125 |
| Bio databases IDs | |
| Aliases | phosphopantothenoylcysteine synthetase |
| Synonyms | 6330579B17RIK, CMD2C, FLJ11838, phosphopantothenoylcysteine synthetase, RGD1311399 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPCS often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PRK06732
- protein homodimerization
- enzyme
- phosphopantothenate-cysteine ligase
- identical protein binding
- DNA / pantothenate metabolism flavoprotein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PPCS gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acetyl-CoA biosynthetic process
- coenzyme A biosynthetic process
- heart process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein homodimerization activity
- phosphopantothenate--cysteine ligase activity