MGAT3 Gene Summary [Human]
There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. The enzyme encoded by this gene transfers a GlcNAc residue to the beta-linked mannose of the trimannosyl core of N-linked oligosaccharides and produces a bisecting GlcNAc. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | MGAT3 |
| Official Name | beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase [Source:HGNC Symbol;Acc:HGNC:7046] |
| Ensembl ID | ENSG00000128268 |
| Bio databases IDs | |
| Aliases | beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
| Synonyms | 1110038J12Rik, beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase, CD99L2 isoform 2, GNT3, GNT-III, LOC100044697, mannoside acetylglucosaminyltransferase 3, β-1,4-mannosyl-glycoprotein 4-β-N-acetylglucosaminyltransferase |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MGAT3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- enzyme
- protein binding
- glycosyltransferase
- beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
- Glycosyltransferase family 17
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- mammary neoplasm
- metastasis
- neoplasia
- breast cancer
- androgenic alopecia
- schizophrenia
- primary open-angle glaucoma
- tumorigenesis
role in cell
- expression in
- phosphorylation in
- activation in
- migration
- apoptosis
- proliferation
- growth
- quantity
- differentiation
- induction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Golgi membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MGAT3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cognition
- protein localization
- protein N-linked glycosylation
- cellular response to oxidative stress
- N-acetylglucosamine metabolic process
- regulation of cell migration
- beta-amyloid metabolic process
Cellular Component
Where in the cell the gene product is active
- membrane
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity
- transferase activity, transferring glycosyl groups
- protein binding