Mgat3 Gene Summary [Mouse]
Enables beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity. Acts upstream of or within several processes, including negative regulation of lysosomal protein catabolic process; positive regulation of protein localization to early endosome; and protein N-linked glycosylation. Predicted to be located in Golgi membrane and lysosome. Is expressed in several structures, including alimentary system; metanephros; and nervous system. Orthologous to human MGAT3 (beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mgat3 |
| Official Name | mannoside acetylglucosaminyltransferase 3 [Source:MGI Symbol;Acc:MGI:104532] |
| Ensembl ID | ENSMUSG00000042428 |
| Bio databases IDs | |
| Aliases | mannoside acetylglucosaminyltransferase 3 |
| Synonyms | 1110038J12Rik, beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase, CD99L2 isoform 2, GNT3, GNT-III, LOC100044697, mannoside acetylglucosaminyltransferase 3, β-1,4-mannosyl-glycoprotein 4-β-N-acetylglucosaminyltransferase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mgat3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- enzyme
- protein binding
- glycosyltransferase
- beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
- Glycosyltransferase family 17
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- mammary neoplasm
- metastasis
- neoplasia
- breast cancer
- androgenic alopecia
- schizophrenia
- primary open-angle glaucoma
- tumorigenesis
role in cell
- expression in
- phosphorylation in
- activation in
- migration
- apoptosis
- proliferation
- growth
- quantity
- differentiation
- induction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Golgi membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mgat3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cognition
- protein localization
- protein N-linked glycosylation
- cellular response to oxidative stress
- N-acetylglucosamine metabolic process
- regulation of cell migration
- beta-amyloid metabolic process
Cellular Component
Where in the cell the gene product is active
- membrane
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity
- transferase activity, transferring glycosyl groups
- protein binding