APOBEC3F Gene Summary [Human]
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | APOBEC3F |
| Official Name | apolipoprotein B mRNA editing enzyme catalytic subunit 3F [Source:HGNC Symbol;Acc:HGNC:17356] |
| Ensembl ID | ENSG00000128394 |
| Bio databases IDs | |
| Aliases | apolipoprotein B mRNA editing enzyme catalytic subunit 3F |
| Synonyms | A3F, apolipoprotein B mRNA editing enzyme catalytic subunit 3F, ARP8, BK150C2.4.MRNA, KA6 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human APOBEC3F often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- APOBEC2
- cytidine_deaminase-like
- Activation induced deaminase
- APOBEC-like N-terminal domain
- enzyme
- protein binding
- APOBEC4-like -AID/APOBEC-deaminase
- APOBEC1
- identical protein binding
- Secreted Novel AID/APOBEC-like Deaminase 4
- RNA binding
- APOBEC3
- zinc ion binding
- cytidine deaminase
- Novel AID APOBEC clade 2
- Novel AID APOBEC clade 1
- APOBEC4
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- infection
- polyglandular autoimmune syndrome type 1
role in cell
- synthesis in
- replication in
- integration in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic mRNA processing body
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human APOBEC3F gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of retroviral genome replication
- clearance of foreign intracellular DNA
- negative regulation of viral reproduction
- cytidine deamination
- positive regulation of defense response to virus by host
- hypomethylation of CpG island
- DNA cytosine deamination
- negative regulation of transposition, RNA-mediated
- innate immune response
- defense response to virus
- base conversion or substitution editing
- negative regulation of viral genome replication
- cytidine to uridine editing
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytoplasmic mRNA processing body
- apolipoprotein B mRNA editing enzyme complex
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- zinc ion binding
- RNA binding
- protein binding
- cytidine deaminase activity