IL27 Gene Summary [Human]
The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR). [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | IL27 |
| Official Name | interleukin 27 [Source:HGNC Symbol;Acc:HGNC:19157] |
| Ensembl ID | ENSG00000197272 |
| Bio databases IDs | |
| Aliases | interleukin 27 |
| Synonyms | IL-27-A, IL-27p28, IL30, interleukin 27, p28, RGD1561420 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IL27 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- interleukin-27 receptor binding
- poly(Glu) domain
- protein binding
- receptor binding
- cytokine
Pathways
Biological processes and signaling networks where the IL27 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- experimental autoimmune encephalomyelitis
- COVID-19
- neoplasia
- glioma
- glioma formation
- bacteremia
- allergic airway inflammation
- stenosis
- visceral leishmaniasis
- airway hyperresponsiveness
role in cell
- inhibition in
- expression in
- phosphorylation in
- production in
- cellular infiltration by
- binding
- apoptosis
- survival
- proliferation
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- cytosol
- endoplasmic reticulum lumen
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IL27 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of T cell proliferation
- inflammatory response
- signal transduction
- innate immune response
- positive regulation of interferon-gamma production
- positive regulation of defense response to virus by host
- regulation of T-helper 1 cell differentiation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- cytosol
- extracellular region
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- interleukin-27 receptor binding
- cytokine activity
- receptor binding