PURG Gene Summary [Human]
The exact function of this gene is not known, however, its encoded product is highly similar to purine-rich element binding protein A. The latter is a DNA-binding protein which binds preferentially to the single strand of the purine-rich element termed PUR, and has been implicated in the control of both DNA replication and transcription. This gene lies in close proximity to the Werner syndrome gene, but on the opposite strand, on chromosome 8p11. [provided by RefSeq, Apr 2016]
Details
| Type | Protein Coding |
| Official Symbol | PURG |
| Official Name | purine rich element binding protein G [Source:HGNC Symbol;Acc:HGNC:17930] |
| Ensembl ID | ENSG00000172733 |
| Bio databases IDs | |
| Aliases | purine rich element binding protein G |
| Synonyms | 4930486B15Rik, PURG-A, PURG-B, purine-rich element binding protein G |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PURG often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PUR domain
- Protein of unknown function (DUF3276)
- PurA ssDNA and RNA-binding protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PURG gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- synapse
Molecular Function
What the gene product does at the molecular level
- RNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- purine-rich negative regulatory element binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity