ISLR Gene Summary [Human]
Predicted to be involved in cell adhesion. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ISLR |
| Official Name | immunoglobulin superfamily containing leucine rich repeat [Source:HGNC Symbol;Acc:HGNC:6133] |
| Ensembl ID | ENSG00000129009 |
| Bio databases IDs | |
| Aliases | immunoglobulin superfamily containing leucine rich repeat |
| Synonyms | HsT17563, immunoglobulin superfamily containing leucine-rich repeat, Meflin |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ISLR often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- Leucine rich repeat
- Leucine rich repeat C-terminal domain
- Leucine Rich repeats (2 copies)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastatic colorectal cancer
- Crohn disease
- tumorigenesis
- aortic valve calcification
- autosomal dominant polycystic kidney disease
- androgenic alopecia
- organismal death
- ulcerative colitis
- Hodgkin lymphoma
role in cell
- expression in
- invasion by
- phosphorylation in
- proliferation
- cell viability
- adhesion
- migration
- degradation in
- number
- epithelial-mesenchymal transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- detergent resistant lipid raft fraction
- alpha granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ISLR gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule lumen
- extracellular vesicular exosome
- extracellular region