CCN1 Gene Summary [Human]
The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011]
Details
| Type | Protein Coding |
| Official Symbol | CCN1 |
| Official Name | cellular communication network factor 1 [Source:HGNC Symbol;Acc:HGNC:2654] |
| Ensembl ID | ENSG00000142871 |
| Bio databases IDs | |
| Aliases | cellular communication network factor 1 |
| Synonyms | cellular communication network factor 1, CYR61, Cysteine-rich protein 61, GIG1, IGFBP10 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CCN1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thrombospondin type 1 repeats
- Glycoprotein hormone beta chain homologues
- Thrombospondin type 1 domain
- thrombospondin type 1 repeat
- thrombospondin-1 motif
- extracellular matrix binding
- heparin binding domain
- protein binding
- IGFBP-like domain
- von Willebrand factor type C domain
- C-terminal cysteine knot domain
- integrin binding
- alpha6 beta1 integrin binding domain
- Spondin-like TSP1 domain
- Insulin-like growth factor binding protein
- heparin binding
Pathways
Biological processes and signaling networks where the CCN1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- breast cancer
- epithelial neoplasia
- epithelial cancer
- liver cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
- mammary neoplasm
role in cell
- production in
- phosphorylation in
- synthesis in
- quantity
- expression in
- proliferation
- apoptosis
- survival
- cell death
- molecular cleavage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- apical compartment
- cellular membrane
- Nucleus
- cytosol
- endoplasmic reticulum lumen
- nuclear envelope
- nuclear matrix
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CCN1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- wound healing, spreading of cells
- positive regulation of cartilage development
- intussusceptive angiogenesis
- cell adhesion
- positive regulation of osteoblast differentiation
- positive regulation of transcription from RNA polymerase II promoter
- apoptotic process involved in heart morphogenesis
- chemotaxis
- osteoblast differentiation
- positive regulation of cell-substrate adhesion
- positive regulation of bone mineralization
- positive regulation of osteoblast proliferation
- signal transduction
- chondroblast differentiation
- atrioventricular valve morphogenesis
- ventricular septum development
- positive regulation of cell differentiation
- atrial septum morphogenesis
- chorio-allantoic fusion
- positive regulation of BMP signaling pathway
- regulation of ERK1 and ERK2 cascade
- reactive oxygen species metabolic process
- labyrinthine layer blood vessel development
- positive regulation of protein kinase activity
- negative regulation of apoptotic process
- positive regulation of apoptotic process
- positive regulation of protein phosphorylation
- extracellular matrix organization
- positive regulation of ceramide biosynthetic process
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
Molecular Function
What the gene product does at the molecular level
- extracellular matrix binding
- growth factor binding
- protein binding
- integrin binding
- heparin binding
- extracellular matrix structural constituent