MOSPD2 Gene Summary [Human]
Involved in positive regulation of monocyte chemotaxis and positive regulation of neutrophil chemotaxis. Located in endoplasmic reticulum and endoplasmic reticulum-endosome membrane contact site. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | MOSPD2 |
| Official Name | motile sperm domain containing 2 [Source:HGNC Symbol;Acc:HGNC:28381] |
| Ensembl ID | ENSG00000130150 |
| Bio databases IDs | |
| Aliases | motile sperm domain containing 2 |
| Synonyms | 2410013I23Rik, motile sperm domain containing 2, RGD1563952 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MOSPD2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain in homologues of a S
- Divergent CRAL/TRIO domain
- CRAL/TRIO domain
- protein domain specific binding
- protein binding
- MSP (Major sperm protein) domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- Plasma Membrane
- Endoplasmic Reticulum
- Mitochondria
- specific granule membrane
- endoplasmic reticulum membrane
- organelle membrane contact site
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MOSPD2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chemotaxis
- positive regulation of monocyte chemotaxis
- positive regulation of neutrophil chemotaxis
- protein homooligomerization
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- organelle membrane contact site
- membrane
- endomembrane system
- endoplasmic reticulum
- plasma membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- FFAT motif binding