ZFYVE27 Gene Summary [Human]
This gene encodes a protein with several transmembrane domains, a Rab11-binding domain and a lipid-binding FYVE finger domain. The encoded protein appears to promote neurite formation. A mutation in this gene has been reported to be associated with hereditary spastic paraplegia, however the pathogenicity of the mutation, which may simply represent a polymorphism, is unclear. [provided by RefSeq, Mar 2010]
Details
| Type | Protein Coding |
| Official Symbol | ZFYVE27 |
| Official Name | zinc finger FYVE-type containing 27 [Source:HGNC Symbol;Acc:HGNC:26559] |
| Ensembl ID | ENSG00000155256 |
| Bio databases IDs | |
| Aliases | zinc finger FYVE-type containing 27, protrudin |
| Synonyms | 2210011N02RIK, 9530077C24Rik, AI426636, PROTRUDIN, SPG33, zinc finger, FYVE domain containing 27, zinc finger FYVE-type containing 27 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZFYVE27 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FYVE domain like superfamily
- FYVE zinc finger
- Protein present in Fab1, YOTB, Vac1, and EEA1
- FFAT motif
- PHD finger superfamily
- coiled-coil domain
- protein binding
- identical protein binding
- hydrophobic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperactive behavior
- hereditary spastic paraplegia autosomal dominant 33
- preeclampsia
role in cell
- binding in
- degradation in
- formation
- morphogenesis
- outgrowth
- invasion by
- degradation by
- exocytosis by
- formation in
- outgrowth in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- endoplasmic reticulum tubules
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
- endosomal membrane
- nucleoplasm
- growth cone
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZFYVE27 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nerve growth factor receptor signaling pathway
- vesicle-mediated transport
- neuron projection development
- endoplasmic reticulum tubular network assembly
- positive regulation of axon extension
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- dendrite
- intracellular membrane-bounded organelle
- endoplasmic reticulum tubular network
- cytosol
- growth cone membrane
- endoplasmic reticulum
- recycling endosome membrane
- axon
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- metal ion binding