TUBGCP2 Gene Summary [Human]
Predicted to enable gamma-tubulin binding activity. Predicted to contribute to microtubule minus-end binding activity. Involved in brain development and neuron migration. Located in centrosome and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TUBGCP2 |
| Official Name | tubulin gamma complex associated protein 2 [Source:HGNC Symbol;Acc:HGNC:18599] |
| Ensembl ID | ENSG00000130640 |
| Bio databases IDs | |
| Aliases | tubulin gamma complex associated protein 2 |
| Synonyms | 1700022B05Rik, ALP4, GCP-2, Grip103, h103p, hGCP2, hSpc97, PAMDDFS, SPBC97, SPC97, Spc97p, tubulin gamma complex component 2, tubulin, gamma complex component 2, tubulin γ complex component 2, tubulin, γ complex component 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TUBGCP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptidase
- protein binding
- Gamma tubulin complex component N-terminal
- Gamma tubulin complex component C-terminal
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pachygyria, microcephaly, developmental delay, and dysmorphic facies with or without seizures
regulates
- protein-protein complex
role in cell
- migration
- assembly
- nucleation in
- nucleation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- basal bodies
- centrosome
- microtubule organizing centers
- cytosol
- nucleoplasm
- nuclear envelope
- cytoplasmic microtubule
- mitotic spindle
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TUBGCP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spindle assembly
- meiotic cell cycle
- neuron migration
- macromolecular complex assembly
- microtubule nucleation
- brain development
- cytoplasmic microtubule organization
- mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- centrosome
- microtubule organizing center
- membrane
- equatorial microtubule organizing center
- spindle pole
- cytosol
- cytoplasmic microtubule
- gamma-tubulin complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- microtubule minus-end binding
- gamma-tubulin binding