Tubgcp2 Gene Summary [Mouse]
Predicted to enable gamma-tubulin binding activity. Predicted to contribute to microtubule minus-end binding activity. Predicted to be involved in several processes, including meiotic cell cycle; microtubule cytoskeleton organization; and nervous system development. Predicted to be located in centrosome and nucleoplasm. Predicted to be part of gamma-tubulin complex. Is expressed in cerebral cortex; cerebral cortex ventricular layer; and cortical plate. Human ortholog(s) of this gene implicated in pachygyria, microcephaly, developmental delay, and dysmorphic facies, with or without seizures. Orthologous to human TUBGCP2 (tubulin gamma complex component 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Tubgcp2 |
| Official Name | tubulin, gamma complex associated protein 2 [Source:MGI Symbol;Acc:MGI:1921487] |
| Ensembl ID | ENSMUSG00000025474 |
| Bio databases IDs | |
| Aliases | tubulin, gamma complex associated protein 2 |
| Synonyms | 1700022B05Rik, ALP4, GCP-2, Grip103, h103p, hGCP2, hSpc97, PAMDDFS, SPBC97, SPC97, Spc97p, tubulin gamma complex component 2, tubulin, gamma complex component 2, tubulin γ complex component 2, tubulin, γ complex component 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tubgcp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptidase
- protein binding
- Gamma tubulin complex component N-terminal
- Gamma tubulin complex component C-terminal
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pachygyria, microcephaly, developmental delay, and dysmorphic facies with or without seizures
regulates
- protein-protein complex
role in cell
- migration
- assembly
- nucleation in
- nucleation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- basal bodies
- centrosome
- microtubule organizing centers
- cytosol
- nucleoplasm
- nuclear envelope
- cytoplasmic microtubule
- mitotic spindle
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tubgcp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spindle assembly
- meiotic cell cycle
- neuron migration
- macromolecular complex assembly
- microtubule nucleation
- brain development
- cytoplasmic microtubule organization
- mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- centrosome
- microtubule organizing center
- membrane
- equatorial microtubule organizing center
- spindle pole
- cytosol
- cytoplasmic microtubule
- gamma-tubulin complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- microtubule minus-end binding
- gamma-tubulin binding