EIF3G Gene Summary [Human]
This gene encodes a core subunit of the eukaryotic translation initiation factor 3 (eIF3) complex, which is required for initiation of protein translation. An N-terminal caspase cleavage product of the encoded protein may stimulate degradation of DNA. A mutation in this gene is associated with narcolepsy. [provided by RefSeq, Jul 2016]
Details
| Type | Protein Coding |
| Official Symbol | EIF3G |
| Official Name | eukaryotic translation initiation factor 3 subunit G [Source:HGNC Symbol;Acc:HGNC:3274] |
| Ensembl ID | ENSG00000130811 |
| Bio databases IDs | |
| Aliases | eukaryotic translation initiation factor 3 subunit G |
| Synonyms | D0Jmb4, eIF3-delta, EIF3-P42, eIF3-p44, EIF3S4, eIF3-δ, Eukaryotic translation initiation factor 3 (p42 subunit), eukaryotic translation initiation factor 3 subunit G, eukaryotic translation initiation factor 3, subunit G, p44, TU-189B2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human EIF3G often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- eIF3G
- translation initiation factor
- protein binding
- translation regulator
- RNA binding
Pathways
Biological processes and signaling networks where the EIF3G gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- narcolepsy with cataplexy
- aortic valve calcification
- infection by vesicular stomatitis virus
role in cell
- cell death
- production in
- replication in
- translation in
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human EIF3G gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- formation of translation initiation complex
- translational initiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- eukaryotic 43S preinitiation complex
- cytosol
- eukaryotic 48S preinitiation complex
- eukaryotic translation initiation factor 3 complex
Molecular Function
What the gene product does at the molecular level
- translation initiation factor activity
- RNA binding
- protein binding