BPIFA2 Gene Summary [Human]
This gene encodes a member of the palate, lung and nasal epithelium clone (Plunc) family of proteins. Members of this family have been proposed to play a role in the local antibacterial response in nose, mouth and upper respiratory pathways. The encoded soluble salivary protein binds bacterial lipopolysaccharide (LPS) and inhibits bacterial growth. This gene is present in a gene cluster on chromosome 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Details
| Type | Protein Coding |
| Official Symbol | BPIFA2 |
| Official Name | BPI fold containing family A member 2 [Source:HGNC Symbol;Acc:HGNC:16203] |
| Ensembl ID | ENSG00000131050 |
| Bio databases IDs | |
| Aliases | BPI fold containing family A member 2 |
| Synonyms | bA49G10.1, Bpifa2e, BPI fold containing family A member 2, BPI fold containing family A, member 2, C20orf70, PSP, SPLUNC2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BPIFA2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- BPI
- lipopolysaccharide binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- secretory granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BPIFA2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- defense response to bacterium
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- secretory granule
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- lipopolysaccharide binding