ELF5 Gene Summary [Human]
This gene encodes an epithelium-specific ETS family transcription factor. In addition to its role in regulating the later stages of terminal differentiation of keratinocytes, it appears to regulate a number of epithelium-specific genes found in tissues containing glandular epithelium such as salivary gland and prostate. It has very low affinity to DNA due to its negative regulatory domain at the amino terminus. This gene has been implicated as a tumor suppressive transcription factor in breast cancer. [provided by RefSeq, May 2022]
Details
| Type | Protein Coding |
| Official Symbol | ELF5 |
| Official Name | E74 like ETS transcription factor 5 [Source:HGNC Symbol;Acc:HGNC:3320] |
| Ensembl ID | ENSG00000135374 |
| Bio databases IDs | |
| Aliases | E74 like ETS transcription factor 5 |
| Synonyms | E74 like ETS transcription factor 5, E74-like factor 5, ESE-2, ESE-5, ESE-5. |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ELF5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- Sterile alpha motif (SAM)/Pointed domain
- transcription regulator
- nucleic acid binding
- double-stranded DNA binding
- SAM (Sterile alpha motif )
- Ets-domain
- protein binding
- sequence-specific DNA binding
Pathways
Biological processes and signaling networks where the ELF5 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- androgenic alopecia
- COVID-19
- lung adenocarcinoma
- lung adenocarcinoma formation
- primary pulmonary hypertension
- failure of lactation
- critical COVID-19
- renal clear cell adenocarcinoma
role in cell
- apoptosis
- growth
- expression in
- proliferation
- phosphorylation in
- quantity
- accumulation in
- differentiation
- accumulation
- epithelial-mesenchymal transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ELF5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell differentiation
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity