ELF3
ELF3 Gene Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in inflammatory response; negative regulation of transcription, DNA-templated; and positive regulation of transcription by RNA polymerase II. Located in Golgi apparatus; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ELF3 |
| Official Name | E74 like ETS transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:3318] |
| Ensembl ID | ENSG00000163435 |
| Bio databases IDs | |
| Aliases | E74 like ETS transcription factor 3 |
| Synonyms | E74 like ETS transcription factor 3,E74-like factor 3,EPR-1,ERT,ESE-1,ESX,jen,RP11-510N19.1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- transcription regulator
- autoinhibitory protein domain
- DNA binding domain
- nucleic acid binding
- SAM (Sterile alpha motif )
- TBP binding domain
- transcription activation domain
- protein binding
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- Sterile alpha motif (SAM)/Pointed domain
- serine and aspartic acid-rich domain
- double-stranded DNA binding
- Ets-domain
- pointed domain
- AT hook domain
- transcription factor activity
Pathways
Biological processes and signaling networks where the ELF3 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- JUN
- AR
- PTGS2
- DLX3
- TARS1
- COL2A1
- ILF2
- TRIM24
- NOS2
- EWSR1
disease
- biliary tract cancer
- osteoarthritis
- epithelial cancer
- epithelial neoplasia
- cancer
- endometriosis
- breast cancer
- organismal death
- systemic lupus erythematosus
- ampullary cancer
regulated by
- cisplatin
- IL1B
- palmitic acid
- TNF
- lipopolysaccharide
- atorvastatin
- Immunoglobulin
- allopurinol
- 2-bromoethylamine
- beta-estradiol
regulates
- IL6
- PPARG
- NOS2
- IL4
- FN1
- PTGS2
- ERK1/2
- DNA promoter
- synthetic promoter
- NFKB1
role in cell
- expression in
- growth
- proliferation
- transcription in
- activation in
- cell viability
- adhesion
- differentiation
- migration
- stimulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nuclear matrix fraction
- Cytoplasm
- Golgi Apparatus
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the ELF3 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- mammary gland involution
- inflammatory response
- negative regulation of transcription, DNA-dependent
- blastocyst development
- extracellular matrix organization
- cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- cytosol
- Golgi apparatus
- chromatin
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity