VPS25
VPS25 Gene Summary
This gene encodes a protein that is a subunit of the endosomal sorting complex required for transport II (ESCRT-II). This protein complex functions in sorting of ubiquitinated membrane proteins during endocytosis. A pseudogene of this gene is present on chromosome 1. [provided by RefSeq, Jul 2013]
Details
| Type | Protein Coding |
| Official Symbol | VPS25 |
| Official Name | vacuolar protein sorting 25 homolog [Source:HGNC Symbol;Acc:HGNC:28122] |
| Ensembl ID | ENSG00000131475 |
| Bio databases IDs | |
| Aliases | vacuolar protein sorting 25 homolog |
| Synonyms | 1110020N13Rik,D11Wsu68e,DERP9,EAP20,FAP20,vacuolar protein sorting 25,vacuolar protein sorting 25 homolog |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ESCRT-II complex subunit
- protein homodimerization
- protein binding
Pathways
Biological processes and signaling networks where the VPS25 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- REL
- HSPA1A
- SNF8
- VPS36
- VAMP3
- NCBP1
- MVB12A
- PTPRE
- STING1
- RHOXF2
disease
- organismal death
regulated by
- VPS4B
- SNF8
- CST5
- NRAS
- 144DG11
regulates
- EGFR
- SLC40A1
role in cell
- assembly
- downregulation in
- macroautophagy in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Nucleus
- cytosol
- endosomal membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the VPS25 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
- membrane fission
- negative regulation of epidermal growth factor-activated receptor activity
- macroautophagy
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- intracellular membrane-bounded organelle
- ESCRT II complex
- cytosol
- endosome membrane
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity
- structural molecule activity