PTPRE Gene Summary [Human]
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Several alternatively spliced transcript variants of this gene have been reported, at least two of which encode a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokine-induced SATA signaling, as well as the activation of voltage-gated K+ channels. [provided by RefSeq, Oct 2015]
Details
| Type | Protein Coding |
| Official Symbol | PTPRE |
| Official Name | protein tyrosine phosphatase receptor type E [Source:HGNC Symbol;Acc:HGNC:9669] |
| Ensembl ID | ENSG00000132334 |
| Bio databases IDs | |
| Aliases | protein tyrosine phosphatase receptor type E |
| Synonyms | HPTPE, protein tyrosine phosphatase receptor type E, protein tyrosine phosphatase, receptor type, E, PTPE, PTPepsilon, Ptp epsilon C, Ptp epsilon M, Ptp ε, Ptp ε C, Ptp ε M, R-PTP-EPSILON, R-PTP-ε, TIGR--HG620-HT620 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PTPRE often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- protein-tyrosine-phoshatase
- Protein tyrosine phosphatase, catalytic domain
- PTP_DSP_cys
- protein binding
- phosphatase domain
- identical protein binding
- Protein tyrosine phosphatase, catalytic domain motif
- PTPase domain
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- Protein-tyrosine phosphatase
- transmembrane receptor protein tyrosine phosphatase
- transmembrane domain
- phosphatase
- tyrosine phosphorylation site
Pathways
Biological processes and signaling networks where the PTPRE gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- septic shock
- Huntington disease
- Alzheimer disease
- primary cardiomyopathy
- diabetic nephropathy
- demyelination
- sarcoidosis
- breast cancer
- epithelial cancer
- myelodysplastic syndrome
role in cell
- proliferation
- activation in
- activation
- cell viability
- apoptosis
- phosphorylation in
- expression in
- growth
- morphology
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- nuclear fraction
- membrane fraction
- Cytoplasm
- cell surface
- cellular membrane
- Nucleus
- cytosol
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PTPRE gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein dephosphorylation
- negative regulation of insulin receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein tyrosine phosphatase activity
- transmembrane receptor protein tyrosine phosphatase activity