VPS36 Gene Summary [Human]
This gene encodes a protein that is a subunit of the endosomal sorting complex required for transport II (ESCRT-II). This protein complex functions in sorting of ubiquitinated membrane proteins during endocytosis. A similar protein complex in rat is associated with RNA polymerase elongation factor II. [provided by RefSeq, Aug 2013]
Details
| Type | Protein Coding |
| Official Symbol | VPS36 |
| Official Name | vacuolar protein sorting 36 homolog [Source:HGNC Symbol;Acc:HGNC:20312] |
| Ensembl ID | ENSG00000136100 |
| Bio databases IDs | |
| Aliases | vacuolar protein sorting 36 homolog |
| Synonyms | 1700010A24Rik, 2210415M20RIK, 2810408E15RIK, C13ORF9, CGI-145, EAP45, RGD1309754, vacuolar protein sorting 36, vacuolar protein sorting 36 homolog |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human VPS36 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EAP30/Vps36 family
- ubiquitin binding
- protein binding
- Pleckstrin homology-like domain
Pathways
Biological processes and signaling networks where the VPS36 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endosomes
- lysosome
- Golgi Apparatus
- cytosol
- endosomal membrane
- late endosomes
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human VPS36 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
- membrane fission
- macroautophagy
Cellular Component
Where in the cell the gene product is active
- late endosome membrane
- nucleus
- extracellular vesicular exosome
- endosome
- ESCRT II complex
- cytosol
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin binding
- phosphatidylinositol-3-phosphate binding