TRAF7 Gene Summary [Human]
Tumor necrosis factor (TNF; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF receptor superfamily (see MIM 191190). TRAFs are composed of an N-terminal cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs; a coiled-coil (leucine zipper) motif; and a homologous region that defines the TRAF family, the TRAF domain, which is involved in self-association and receptor binding.[supplied by OMIM, Apr 2004]
Details
| Type | Protein Coding |
| Official Symbol | TRAF7 |
| Official Name | TNF receptor associated factor 7 [Source:HGNC Symbol;Acc:HGNC:20456] |
| Ensembl ID | ENSG00000131653 |
| Bio databases IDs | |
| Aliases | TNF receptor associated factor 7 |
| Synonyms | CAFDADD, RFWD1, RGD1559653, RNF119, TNF receptor-associated factor 7 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRAF7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase activity
- WD domain, G-beta repeat
- coiled-coil domain
- WD40
- enzyme
- TRAF domain
- protein binding
- WD40 repeats
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Modified RING finger domain
- Ring finger
- ubiquitin-protein transferase activity
- Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I
- zinc finger domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- benign neoplasia
- cardiac, facial and digital anomalies with developmental delay
- uterine leiomyosarcoma
- uterine cancer
- soft tissue sarcoma cancer
- prostate cancer
- hereditary disorder
- genital adenomatoid tumor
- mesothelioma formation
- localized pleural mesothelioma
role in cell
- cell death
- expression in
- phosphorylation in
- production in
- apoptosis
- activation in
- number
- invasion by
- cell viability
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- perinuclear region
- Nucleus
- Plasma Membrane
- cytosol
- vesicle fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRAF7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
- regulation of ERK1 and ERK2 cascade
- Notch signaling pathway
- protein K29-linked ubiquitination
- apoptotic process
- positive regulation of MAPK cascade
- ribosomal large subunit assembly
- positive regulation of neuron apoptotic process
- positive regulation of apoptotic signaling pathway
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- ubiquitin ligase complex
- intracellular membrane-bounded organelle
- cytoplasmic vesicle
- nucleolus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- zinc ion binding
- protein binding