PIAS3 Gene Summary [Human]
This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Details
| Type | Retained Intron |
| Official Symbol | PIAS3 |
| Official Name | protein inhibitor of activated STAT 3 [Source:HGNC Symbol;Acc:HGNC:16861] |
| Ensembl ID | ENSG00000131788 |
| Bio databases IDs | |
| Aliases | protein inhibitor of activated STAT 3, zinc finger, MIZ-type containing 5 |
| Synonyms | KChAP, LOC101060431, LOC83614, Pias3l, protein inhibitor of activated STAT 3, protein inhibitor of activated STAT, 3, ZMIZ5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PIAS3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PINIT domain
- transcription regulator
- LXXLL motif
- SUMO transferase activity
- SUMO interaction motif
- NF-kappaB binding
- potassium channel regulator
- protein binding
- SAP30 binding domain
- ionotropic glutamate receptor binding
- acidic domain
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- MIZ/SP-RING zinc finger
- ion channel binding
Pathways
Biological processes and signaling networks where the PIAS3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- spinocerebellar ataxia type 7
- rheumatoid arthritis
- Huntington disease
- intellectual disability and developmental delay
- survival
role in cell
- migration
- activation in
- expression in
- apoptosis
- growth
- formation
- differentiation
- osteoclastogenesis
- sumoylation in
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- glutaminergic synapse
- Cytoplasm
- cytosol
- nuclear foci
- nucleoplasm
- nuclear speckles
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PIAS3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of gene expression
- protein sumoylation
- negative regulation of osteoclast differentiation
- regulation of tumor necrosis factor-mediated signaling pathway
- positive regulation of protein sumoylation
- negative regulation of protein sumoylation
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- nuclear speck
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- transcription cofactor activity
- SUMO ligase activity