RHPN2 Gene Summary [Human]
This gene encodes a member of the rhophilin family of Ras-homologous (Rho)-GTPase binding proteins. The encoded protein binds both GTP- and GDP-bound RhoA and GTP-bound RhoB and may be involved in the organization of the actin cytoskeleton. [provided by RefSeq, Apr 2009]
Details
| Type | Protein Coding |
| Official Symbol | RHPN2 |
| Official Name | rhophilin Rho GTPase binding protein 2 [Source:HGNC Symbol;Acc:HGNC:19974] |
| Ensembl ID | ENSG00000131941 |
| Bio databases IDs | |
| Aliases | rhophilin Rho GTPase binding protein 2 |
| Synonyms | 1300002E07Rik, D7Ertd784e, P76RBE, RHOBP, rhophilin Rho GTPase binding protein 2, rhophilin, Rho GTPase binding protein 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RHPN2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein-interacting Bro1-like domain of mammalian Alix and related domains
- Domain present in PSD-95, Dlg, and ZO-1/2
- BRO1-like domain
- canonical PDZ domain
- PDZ domain
- Rho-binding domain
- Hr1 repeat
- HR1
Pathways
Biological processes and signaling networks where the RHPN2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- colon carcinoma
- colon epithelial cancer
- cleft palate with cleft lip
- ischemic stroke
- colorectal adenoma
- colorectal adenoma formation
- gastroesophageal reflux
regulates
- actin
- RHOA
role in cell
- loss
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RHPN2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of stress fiber assembly
- signal transduction
- glomerular filtration
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- cytosol
- plasma membrane