VPS26B Gene Summary [Human]
Predicted to be involved in intracellular protein transport and retrograde transport, endosome to Golgi. Predicted to act upstream of or within cellular response to interferon-gamma. Predicted to be located in early endosome and late endosome. Predicted to be part of retromer complex. Predicted to be active in endosome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | VPS26B |
| Official Name | VPS26, retromer complex component B [Source:HGNC Symbol;Acc:HGNC:28119] |
| Ensembl ID | ENSG00000151502 |
| Bio databases IDs | |
| Aliases | VPS26, retromer complex component B, VPS26 retromer complex component B |
| Synonyms | 1810012I05RIK, 2310075A12Rik, AI848392, Pep8b, VPS26 retromer complex component B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human VPS26B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Vacuolar protein sorting-associated protein 26
- protein binding
- Arrestin (or S-antigen), N-terminal domain
- transporter
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- endosomes
- recycling endosomes
- early endosomes
- late endosomes
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human VPS26B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of macroautophagy
- cellular response to interferon-gamma
- retrograde transport, endosome to Golgi
- intracellular protein transport
Cellular Component
Where in the cell the gene product is active
- early endosome
- endosome
- retromer complex
- phagocytic vesicle
- late endosome
- cytosol
- retromer complex, inner shell
Molecular Function
What the gene product does at the molecular level
- protein binding