Ptpre Gene Summary [Mouse]
Enables identical protein binding activity and protein tyrosine phosphatase activity. Involved in negative regulation of insulin receptor signaling pathway and regulation of mast cell activation. Acts upstream of or within cell surface receptor protein tyrosine phosphatase signaling pathway. Located in cytoplasm and plasma membrane. Is expressed in midbrain and superior colliculus. Orthologous to human PTPRE (protein tyrosine phosphatase receptor type E). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptpre |
| Official Name | protein tyrosine phosphatase, receptor type, E [Source:MGI Symbol;Acc:MGI:97813] |
| Ensembl ID | ENSMUSG00000041836 |
| Bio databases IDs | |
| Aliases | protein tyrosine phosphatase, receptor type, E |
| Synonyms | HPTPE, protein tyrosine phosphatase receptor type E, protein tyrosine phosphatase, receptor type, E, PTPE, PTPepsilon, Ptp epsilon C, Ptp epsilon M, Ptp ε, Ptp ε C, Ptp ε M, R-PTP-EPSILON, R-PTP-ε, TIGR--HG620-HT620 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ptpre often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- protein-tyrosine-phoshatase
- Protein tyrosine phosphatase, catalytic domain
- PTP_DSP_cys
- protein binding
- phosphatase domain
- identical protein binding
- Protein tyrosine phosphatase, catalytic domain motif
- PTPase domain
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- Protein-tyrosine phosphatase
- transmembrane receptor protein tyrosine phosphatase
- transmembrane domain
- phosphatase
- tyrosine phosphorylation site
Pathways
Biological processes and signaling networks where the Ptpre gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- septic shock
- Huntington disease
- Alzheimer disease
- primary cardiomyopathy
- diabetic nephropathy
- demyelination
- sarcoidosis
- breast cancer
- epithelial cancer
- myelodysplastic syndrome
role in cell
- proliferation
- activation in
- activation
- cell viability
- apoptosis
- phosphorylation in
- expression in
- growth
- morphology
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- nuclear fraction
- membrane fraction
- Cytoplasm
- cell surface
- cellular membrane
- Nucleus
- cytosol
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ptpre gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein dephosphorylation
- negative regulation of insulin receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein tyrosine phosphatase activity
- transmembrane receptor protein tyrosine phosphatase activity