SLA Gene Summary [Human]
Predicted to enable signaling receptor binding activity. Predicted to be involved in cell differentiation; innate immune response; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to be located in cytosol. Predicted to be active in dendritic spine and focal adhesion. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SLA |
| Official Name | Src like adaptor [Source:HGNC Symbol;Acc:HGNC:10902] |
| Ensembl ID | ENSG00000155926 |
| Bio databases IDs | |
| Aliases | Src like adaptor |
| Synonyms | SLA1, SLAP, Slap-1, Src like adaptor |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Src homology 2 (SH2) domain
- protein binding
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- peripheral arterial disease
- androgenic alopecia
- multiple sclerosis
- latent tuberculosis
- Waldenström macroglobulinemia
role in cell
- activation in
- function
- quantity
- phosphorylation in
- formation
- tyrosine phosphorylation in
- binding in
- S phase
- number
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- perinuclear region
- endosomes
- vesicles
- cytosol
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of MAPK cascade
- signal transduction
Cellular Component
Where in the cell the gene product is active
- endosome
- cytoplasm
- cytosol
- signalosome
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- phosphotyrosine binding
- protein binding
- epidermal growth factor receptor binding