NTF4 Gene Summary [Human]
This gene is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of mammalian neurons. The expression of this gene is ubiquitous and less influenced by environmental signals. While knock-outs of other neurotrophins including nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 prove lethal during early postnatal development, NTF5-deficient mice only show minor cellular deficits and develop normally to adulthood. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | NTF4 |
| Official Name | neurotrophin 4 [Source:HGNC Symbol;Acc:HGNC:8024] |
| Ensembl ID | ENSG00000225950 |
| Bio databases IDs | |
| Aliases | neurotrophin 4, neurotrophic factor 4 |
| Synonyms | 2900040K06Rik, AI462899, GLC10, GLC1O, neurotrophin 4, Neurotrophin 5, NT-4, NT-4/5, NT4P, NT-5, NTF5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NTF4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- neurotrophin p75 receptor binding
- protein binding
- growth factor
- Nerve growth factor family
Pathways
Biological processes and signaling networks where the NTF4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- rheumatoid arthritis
- heat hyperalgesia
- Alzheimer disease
- hereditary disorder
- atopic dermatitis
- open angle glaucoma type 1O
- colon epithelial cancer
- spondylarthritis
- colon adenocarcinoma
role in cell
- synthesis in
- expression in
- differentiation
- apoptosis
- migration
- cell death
- proliferation
- loss
- survival
- length
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- Golgi Apparatus
- endoplasmic reticulum lumen
- nerve ending
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NTF4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory organ boundary specification
- innervation
- neuron projection morphogenesis
- epidermis development
- transmembrane receptor protein tyrosine kinase signaling pathway
- adult locomotory behavior
- nerve development
- negative regulation of neuron apoptotic process
- long-term memory
- mechanoreceptor differentiation
- regulation of synaptic transmission
- taste bud development
- positive regulation of peptidyl-serine phosphorylation
Cellular Component
Where in the cell the gene product is active
- dendrite
- extracellular space
- synaptic vesicle
- extracellular region
- axon
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- nerve growth factor receptor binding