Dcaf8 Gene Summary [Mouse]
Acts upstream of or within myotube cell development. Part of Cul4-RING E3 ubiquitin ligase complex. Is expressed in several structures, including cerebral cortex; liver; lung; metanephros; and spleen. Human ortholog(s) of this gene implicated in giant axonal neuropathy 2. Orthologous to human DCAF8 (DDB1 and CUL4 associated factor 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Dcaf8 |
| Official Name | DDB1 and CUL4 associated factor 8 [Source:MGI Symbol;Acc:MGI:91860] |
| Ensembl ID | ENSMUSG00000026554 |
| Bio databases IDs | |
| Aliases | DDB1 and CUL4 associated factor 8 |
| Synonyms | AA433120, D1Dau35e, D1Ucla4, DDB1 and CUL4 associated factor 8, GAN2, H326, RGD1308513, WDR42A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dcaf8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40 repeats
- WD domain, G-beta repeat
- WD40
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung squamous cell carcinoma
- squamous cell lung cancer
- preeclampsia
- autosomal dominant giant axonal neuropathy 2
regulates
- MYH6
- mir-217 (includes others)
role in cell
- degradation in
- atrophy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Mitochondria
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dcaf8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- mitochondrion
- cytosol
- CUL4 RING ubiquitin ligase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding