PARP14 Gene Summary [Human]
This gene encodes a member of the poly(ADP-ribose) polymerase (PARP) protein family. The encoded anti-apoptotic protein may regulate aerobic glycolysis and promote survival of cancer cells. Increased expression of this gene has been reported in a variety of tumor types. [provided by RefSeq, Jul 2016]
Details
| Type | Protein Coding |
| Official Symbol | PARP14 |
| Official Name | poly(ADP-ribose) polymerase family member 14 [Source:HGNC Symbol;Acc:HGNC:29232] |
| Ensembl ID | ENSG00000173193 |
| Bio databases IDs | |
| Aliases | poly(ADP-ribose) polymerase family member 14 |
| Synonyms | 1600029O10RIK, ARTD8, BAL2, BC021340, CoaSt6, mKIAA1268, pART8, poly (ADP-ribose) polymerase family, member 14, poly(ADP-ribose) polymerase family member 14, RGD1310490 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PARP14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- macro domain
- NAD or NADH binding
- RNA recognition motif (RRM) superfamily
- binding protein
- pentosyltransferase
- NAD ADP-ribosyltransferase
- macrodomain superfamily
- Poly(ADP-ribose) polymerase catalytic domain
- enzyme binding
- enzyme
- protein binding
- ADP_ribosyl
Pathways
Biological processes and signaling networks where the PARP14 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- cervical small cell carcinoma
- extrapulmonary small cell cancer
- epithelial uterine cancer
- cervical cancer
- lymphomagenesis
- insulin-dependent diabetes mellitus
role in cell
- apoptosis
- cell viability
- expression in
- binding in
- replication in
- proliferation
- transcription in
- G1 phase
- survival
- induction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell periphery
- perinuclear region
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PARP14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of gene expression
- negative regulation of transcription, DNA-dependent
- innate immune response
- protein poly-ADP-ribosylation
- positive regulation of tyrosine phosphorylation of STAT protein
- negative regulation of tyrosine phosphorylation of STAT protein
- negative regulation of interferon-gamma-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- membrane
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- nucleotidyltransferase activity
- protein binding
- transcription corepressor activity
- enzyme binding
- NAD+ ADP-ribosyltransferase activity