USPL1 Gene Summary [Human]
Enables SUMO binding activity and SUMO-specific isopeptidase activity. Involved in several processes, including Cajal body organization; protein desumoylation; and snRNA transcription. Located in Cajal body. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | USPL1 |
| Official Name | ubiquitin specific peptidase like 1 [Source:HGNC Symbol;Acc:HGNC:20294] |
| Ensembl ID | ENSG00000132952 |
| Bio databases IDs | |
| Aliases | ubiquitin specific peptidase like 1 |
| Synonyms | bA121O19.1, C13orf22, D13S106E, E430026A01Rik, RGD1310835, ubiquitin specific peptidase like 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human USPL1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SUMO-specific protease
- Domain of unknown function (DUF4650)
- peptidase
- protein binding
- Ubiquitin-specific peptidase-like, SUMO isopeptidase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Cajal bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human USPL1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- protein desumoylation
- proteolysis
- snRNA transcription
- Cajal body organization
Cellular Component
Where in the cell the gene product is active
- extracellular space
- Cajal body
Molecular Function
What the gene product does at the molecular level
- SUMO binding
- protein binding
- ubiquitin binding
- SUMO-specific protease activity