PGD Gene Summary [Human]
6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]
Details
| Type | Protein Coding |
| Official Symbol | PGD |
| Official Name | phosphogluconate dehydrogenase [Source:HGNC Symbol;Acc:HGNC:8891] |
| Ensembl ID | ENSG00000142657 |
| Bio databases IDs | |
| Aliases | phosphogluconate dehydrogenase |
| Synonyms | 0610042A05Rik, 6PGD, 6PGDH, Cc2-27, LOC100363662, phosphogluconate dehydrogenase |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PGD often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 6-phosphogluconate dehydrogenase (decarboxylating)
- Rossmann-fold NAD(P)(+)-binding proteins
- binding protein
- NADP binding
- phosphogluconate 2-dehydrogenase
- NAD binding domain of 6-phosphogluconate dehydrogenase
- 6-phosphogluconate dehydrogenase, C-terminal domain
- phosphogluconate dehydrogenase (decarboxylating)
- enzyme
- carbohydrate binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- psoriasis
- non-insulin-dependent diabetes mellitus
- diabetes mellitus
- androgenic alopecia
- actinic keratosis
- acute myocardial infarction
- primary prostate cancer
regulates
- D-glucose
- fructose-6-phosphate
- PGD dimer
- CYBB
- glucose-6-phosphate
- reactive oxygen species
- lipid
- ribulose 5-phosphate
- NADPH
- D-ribose-5-phosphate
role in cell
- growth
- expression in
- proliferation
- cell viability
- cell death
- accumulation in
- oxygen consumption rate
- biosynthesis in
- pentose shunt in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell periphery
- Nucleus
- microtubule organizing centers
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PGD gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- pentose-phosphate shunt, oxidative branch
- pentose-phosphate shunt
- D-gluconate catabolic process
- pentose biosynthetic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- NADP binding
- phosphogluconate dehydrogenase (decarboxylating) activity